It assumes no prior knowledge of or even interest in biology. is well written … Alon's book is place for physicists to start. " serious attention from any quantitative scientist or physicist who hopes to learn about modern biology. The text avoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. It provides a simple mathematical framework which can be used to understand and even design biological circuits. Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. Includes solved problems after each chapter that detail topics not discussed in the main text.Considers how kinetic proofreading and other mechanisms can minimize errors made in biological information-processing.Details how constrained evolutionary optimization can be used to understand optimal circuit design.Includes examples ranging from bacterial chemotaxis through developmental patterning and neuronal circuits to immune recognition.Explains the basic circuitry in transcription regulation, signal transduction, and developmental networks.It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
All book figures are available online here !Īn Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles.To report typos, please contact Uri Alon.Third printing available from April 2007, about 100 typos corrected.Full solutions Manual for excercises, and powerpoint versions of figures, available or instructors, please contact Uri Alon.Movies of Uri's Course on Systems Biology.
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